The Overlooked Link Between EDS and Testosterone: What You Need to Know

Ehlers-Danlos Syndrome (EDS) is a connective tissue disorder that affects collagen, leading to joint instability, chronic pain, and autonomic dysfunction. While many factors contribute to symptom severity, hormonal imbalances—particularly low testosterone—can play a significant role in worsening EDS symptoms.

Testosterone is essential for muscle strength, connective tissue support, and autonomic function, making it a critical factor in managing EDS symptoms. However, people with EDS—both men and women—may experience low testosterone levels, which can further impact their health.

This blog explores the relationship between EDS and testosterone, how it affects men and women differently, symptoms of low testosterone, and effective management strategies.

The Role of Testosterone in the Body

Testosterone is often associated with male health, but it is equally important for women. It plays a key role in:

• Muscle Mass & Strength – Supports joint stability and prevents excessive laxity.

• Bone Health – Essential for maintaining bone density and reducing fracture risk.

• Collagen Synthesis – Helps repair connective tissue, which is already compromised in EDS.

• Autonomic Nervous System Function – Regulates blood pressure, circulation, and energy levels (important for those with POTS).

• Cognitive & Emotional Health – Affects mood, memory, and concentration.

Testosterone Deficiency in EDS Patients

Many individuals with EDS experience hormonal imbalances, including low testosterone levels. This can happen due to chronic stress, autonomic dysfunction, poor nutrient absorption, and genetic factors.

Symptoms of Low Testosterone in EDS Patients

🦴 Musculoskeletal Symptoms

• Increased joint instability & subluxations

• Muscle weakness leading to poor joint support

• Chronic pain & slower wound healing

• Osteoporosis & higher fracture risk

  
  

🧠 Cognitive & Autonomic Symptoms

• Brain fog & difficulty concentrating

• Chronic fatigue & low energy levels

• Increased dizziness & worsening POTS symptoms

• Anxiety, depression, or mood swings

  
  

How EDS Affects Testosterone Levels Differently in Men & Women

👩 Women with EDS & Testosterone Deficiency

• Women naturally have lower testosterone levels than men, making them more vulnerable to muscle weakness and joint instability.

• Estrogen dominance (especially during menstrual cycles, pregnancy, or menopause) can suppress testosterone production, worsening symptoms.

• POTS & Dysautonomia: Low testosterone may contribute to poor circulation, fatigue, and increased heart rate variability.

• Chronic fatigue & pain may be misattributed to EDS alone when low testosterone is a factor.

  
  

👨 Men with EDS & Testosterone Deficiency

• Men with EDS generally have higher testosterone levels than women, offering some protective benefits (stronger muscle support for joints).

• If testosterone levels drop, men may experience severe fatigue, poor circulation, and worsened autonomic dysfunction (dizziness, low blood pressure).

• Testosterone declines naturally with age, so symptoms may worsen over time.

• Men with EDS and low testosterone may also experience higher pain sensitivity due to its role in nerve function.

Why Do People with EDS Have Lower Testosterone?

There are several possible reasons why individuals with EDS are more prone to low testosterone levels:

1. Chronic Stress & Dysautonomia – Elevated cortisol (stress hormone) suppresses testosterone production.

2. Mitochondrial Dysfunction – Energy production issues common in EDS can reduce hormone synthesis.

3. Nutrient Malabsorption – Poor gut health can lead to deficiencies in zinc, magnesium, and vitamin D, all crucial for testosterone production.

4. Medication Side Effects – Certain medications used for pain, anxiety, or POTS (like beta-blockers) can lower testosterone levels.

5. Hypothalamic-Pituitary-Adrenal (HPA) Axis Dysfunction – The body's hormone regulation system may not function properly in people with EDS.

Managing Low Testosterone in EDS

If you suspect low testosterone, it’s important to get tested and consider lifestyle modifications or medical interventions to optimize levels.

✔️ Key Management Strategies

✔️ Hormone Testing – Ask your doctor for total & free testosterone, estrogen, cortisol, and DHEA levels.

✔️ Resistance Training- is a key factor in naturally supporting testosterone levels. Gentle, well-paced resistance training — like what we use at ParaMotion — can boost both physical function and hormonal balance without overwhelming the system.

✔️ Protein-Rich Diet – Include healthy fats (avocados, nuts, fish, eggs) to support hormone production.

✔️ Adequate Sleep – Testosterone is mainly produced during deep sleep, so aim for 7-9 hours per night.

✔️ Reduce Stress – High cortisol suppresses testosterone— Practices like EDS Movement therapy, deep-breathing, moving meditation and exercises customized to EDS body needs can reduce stress and enhance symptoms. Check our ParaMotion Youtube Channel for movement recommendation or book a consultation with us so that you can get personalized help catered to your body needs.

✔️ Medical Interventions – If levels are very low, consider testosterone replacement therapy (TRT) under medical supervision.

✔️ Hydration & Electrolyte Balance – If you have POTS, maintaining proper fluid & salt intake helps with blood circulation and energy.

Final Thoughts

Low testosterone is often an overlooked factor in EDS but can significantly impact muscle function, joint stability, energy levels, and autonomic health. Recognizing symptoms and addressing hormonal imbalances can lead to better symptom management and quality of life.

If you suspect low testosterone is contributing to your EDS symptoms, testing and personalized treatment can help restore balance and improve daily function.